The Food and Drug Administration requested that pharmaceutical companies reformulate over-the-counter cold remedies and diet aids to exclude PPA in November of 2000. This request occurred in response to a Yale University School of Medicine study that found that PPA increases the risk of hemorrhagic stroke in women.

The FDA is revisiting the classification of PPA this spring in a proposal to reclassify the drug as nonmonograph (Category II)— not generally recognized as safe and effective.

Read more about this ingredient on the FDA’s Phenylpropanolamine (PPA) Information page.

Double check that you are not administering any medications that contain PPA!